Author | Systemic treatment type | Side effects of systemic treatment | Study limitations |
Yu et al.[2] | Post-Operative Oral Bisphosphonates | Two patients reported acid reflux and mild GI distress from the alendronate treatment | Small number of cases and short follow-up time. |
Xu et al. [1] | Peri-Operative IV Bisphosphonates | None—Renal function was monitored in each patient before each infusion. | Retrospective and short follow-up time |
Tse et al. [4] | Peri-Operative IV and Oral Bisphosphonates | None—Renal function was monitored in each patient before each infusion. | Retrospective, short follow-up time in bisphosphonate group, and small sample size. |
Cheng et al. [3] | Preoperative IV Bisphosphonates | Not reported | Short follow-up time, small sample size, and possible confounders. |