Author

Systemic treatment type

Side effects of systemic treatment

Study limitations

Yu et al.[2]

Post-Operative Oral Bisphosphonates

Two patients reported acid reflux and mild GI distress from the alendronate treatment

Small number of cases and short follow-up time.

Xu et al. [1]

Peri-Operative IV Bisphosphonates

None—Renal function was monitored in each patient before each infusion.

Retrospective and short follow-up time

Tse et al. [4]

Peri-Operative IV and Oral Bisphosphonates

None—Renal function was monitored in each patient before each infusion.

Retrospective, short follow-up time in bisphosphonate group, and small sample size.

Cheng et al. [3]

Preoperative IV Bisphosphonates

Not reported

Short follow-up time, small sample size, and possible confounders.